Wednesday, October 31, 2012

Construction Connection Announces Plan to Help Construction ...

Construction Connection?s educational resources target small and medium-sized businesses across the country. They aim to help struggling businesses get back on their feet and bring the construction industry into the 21st century.

Austin, TX (PRWEB) October 30, 2012 -
Construction Connection is launching a plan to offer assistance to small and mid-sized contracting companies, as well as individuals, with their many educational resources and services. Members of?constructionconnection.com, the company?s online industry-specific networking website, have access to a plethora of educational and useful resources including their partners and consulting services, informative blogs, personalized support services and more. In their mission to help individuals and construction companies increase their efficiency and profitability, Construction Connection is working to connect people with experienced experts who can show them how to grow their businesses and expand their skills and knowledge base.

Construction Connection?s website is the gateway to valuable resources for both businesses and individuals. By?registering and completing a free online profile, members can connect with the company?s partners. The?partners are made up of professionals?whose expertise is particularly relevant to the construction industry. Partners include legal firms, engineers, manufacturers, consultants and many more all of whom are available to offer support and guidance. If a contractor has a question about how to best provide benefits to employees, or how the new Patient Protection Affordable Care Act will affect small businesses, he or she can consult the Construction Connection partner the Fringe Benefit Group. For help with complicated legal matters, Smith, Currie & Hancock, LLP offers thoughtful articles and expert counsel. These and other partners are there to help businesses and individuals flourish.

Members of constructionconnection.com can also seek out advice through their blog, support services and even social sites like?Facebook?and?LinkedIn. The blog covers a variety of topics and offers advice on subjects such as personal growth and motivation, how to hire the right individual and how to operate a business more efficiently for greater profitability. The?support services?are also immensely beneficial to members. Not only does Construction Connection boast quality, personalized support, but the co-founders of the company regularly call members on the phone to help them set up their account, enhance their personal profile or post a job opening. For a website that has over 40,000 members, this type of individual attention is unrivaled.

?We see a lot of companies owned and managed by experienced and hard-working contractors, but their businesses are struggling in the current business climate because they don?t know how to market their products and services; lots of companies don?t have a basic marketing plan in place and many don?t even have websites. That?s why we?re so passionate about the support and educational aspect of Construction Connection and?our Consulting SimplifiedTM program,? says Kent Leighton, co-founder of Construction Connection. Leighton and his partner Suzanne Breistol have both been in the construction industry for many years and both know how to run successful and profitable operations. They understand the value of networking with people within their own industry who can offer advice that is relevant and will make a difference.

Leighton and Breistol are determined to help small and mid-sized businesses improve their online presence, hire quality employees and find the answers that will help their businesses grow. They work with individuals to teach them how to best market their skills so that they can find the right job, whether they are a construction accountant, a superintendent or an electrician. ?We?re also here to listen,? says Breistol. ?Sometimes the best service we can provide is just to be a caring person that listens and doesn?t judge, but instead offers feedback and encouragement to help people clarify their thoughts and actions.? Construction Connection aims to help the construction industry continue to recover from a long period of decline by providing a place for people to network, find answers and advice, find a job or a new employee and build their online presence.

Construction Connection was created out of a need for a more effective and streamlined way for construction industry professionals to find the right jobs or hire new, qualified employees and to find answers and solutions to run their businesses more successfully. Construction Connection is a patent-pending, one-of-a-kind profile creating / matchmaking system that delivers effective results. The founders of Construction Connection, both industry professionals themselves, have a passion for connecting people with experts in the industry to help them find smart business solutions; they encourage experts to share their knowledge and act as resources for others. In addition to the networking system, Construction Connection provides free educational resources, so industry professionals can spend as little as 5 minutes at a time learning something new that could enhance their professional careers and grow their businesses. Construction Connection saves you time, money and aggravation by matching people to people, people to companies, companies to people, and companies to companies.

Source: http://www.constructionconnection.com/blog/features/plan-to-help-professionals-and-small-to-mid-sized-contracting-companies-with-industry-basics-for-smart-business/

Art Modell Frank Ocean Gay scarlett johansson bill clinton andy roddick Costa Rica Earthquake sandra fluke

George Lucas: I Sold Lucasfilm To Disney To ?Protect It?

Screen Shot 2012-10-30 at 4.26.43 PMThough it's obviously more of a show business story than it is a technology industry story, the news of Lucasfilm's $4 billion sale to Disney has reverberated throughout the tech world this afternoon. This is partly just because of Star Wars' cult status among the geeks (and I use that term with all respect and love) who make the web go 'round. But also, Lucasfilm has straddled the worlds of tech and film in a unique way, with its headquarters in San Francisco instead of LA and its strong operations in tech- and engineering-heavy things such as visual effects, sound design, animation, and gaming.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/tUujFvf5qI8/

Olympic medal count Medal Count 2012 London 2012 Fencing olympics chariots of fire nbc Medal Count

In Virginia, Obama and Romney camps mount furious final push for votes (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/259478585?client_source=feed&format=rss

gizmodo cnet britney spears sprint Sam Bacile thursday night football At&t Wireless

A Minute With: Rapper RZA putting on "Iron Fists" for new movie

LOS ANGELES (Reuters) - Rapper and music producer RZA is best known as the leader of the hip-hop group the Wu-Tang Clan which also includes such popular members as Method Man, Ghostface Killah and the late Ol' Dirty Bastard.

RZA branched out into film, taking on small acting roles and scoring music, including the soundtrack for Quentin Tarantino's "Kill Bill: Vol. 1."

Now, nearly a decade later, 43-year-old RZA has combined his childhood love of martial arts movies to co-write with Eli Roth the feature film "The Man With the Iron Fists," which he also directs and acts in the title role.

Shot on location in China, and co-starring Russell Crowe and Lucy Liu, Iron Fists is set during the 19th century and sees several groups of warriors and assassins descend on a village in search of gold. The quiet and unassuming local blacksmith (RZA) ends up being the village defender.

RZA, whose real name is Robert Fitzgerald Diggs, sat down with Reuters in Hollywood to talk about the film and the future of the Wu-Tang Clan.

Q: You had to pull double duty, working simultaneously in front and behind the camera. How did you balance that?

A: "My spirit had to be extra strong to pull this off. It was difficult because in the morning (as the director) I'm worrying about everybody else, I'm talking fast. Then I have to get ready for the scene and I gotta sync my voice down to this guy. I gotta sync my spirit to him. He doesn't smile once in the film. I smile. I'm not this morbid dude. He's almost empty."

Q: This is your biggest acting role to date. What did you learn as an actor?

A: "The thing about playing him that I could attest to as an actor was that I was lonely in China. I was personally lonely. And I think that shows on screen (in the character)."

Q: You're in an exotic location with Russell Crowe and some of the biggest names in martial arts. How could you be lonely?

A: "I had no love, yo. You know what I mean? Going into a massage parlor is not gonna give you no love. I was yearning for it. For a brief minute there, I learned why actors fall in love with their co-stars."

Q: How's that?

A: "Because the only girl I had was (co-star/love interest) Jamie Chung. We all went out one night after shooting and Jamie had a guy friend with her. I looked over and I was so jealous. I felt weird. I told my buddy, 'I'm about to punch this guy in the face!' In that moment, I just felt that she was my woman. And the sad thing for me is, it would have been a one way street because she wasn't interested in me at all."

Q: Looking back on your first experience directing a studio movie, what do you think?

A: "It was hard work. It was 18 hour days. It was cold. The food was terrible sometimes and the language was an issue. But I kept it fun. I didn't let nothing deter me from this path. I'm grateful and happy I had a chance to learn this craft and express it. I feel that out of everything I do as an artist - I make music, I write lyrics, I'm into fashion and clothing - filmmaking is the perfect medium and accumulates it all. I found what I should be doing. I matured into being this kind of person."

Q: So many members of the Wu-Tang Clan are doing their own thing. Will you be assembling again soon for another album?

A: "Only time will tell. For now, I will say Iron Fists is Wu-Tang. We have all the members participating on the soundtrack. And if you look closely, you'll notice that when (Rick Yune's character) needs a second suit of knives, there are W's on that second suit. You gotta look closely though. So the Wu-Tang is there. I made it subtly into the film so fans can enjoy it and feel the energy."

Q: Some groups have their time in the spotlight and disappear. Others manage to evolve and stay relevant. Where is Wu-Tang at?

A: "To me, film is the medium that Wu-Tang needs to be at. I don't think Wu-Tang needs to be in clubs while we gettin' drunk and dancing. We need to be in theaters now where we sitting with our families and really appreciating our childhood in a different way. This is the reason why (movies like) 'Iron Man', 'Captain America', 'Thor', 'The Avengers' all work. Because we are adults who read comics and now we want our children to understand what we love."

Q: So Iron Fists is the beginning of that for Wu-Tang - having others understand and appreciate the martial arts you all love?

A: "If Iron Fists goes over well and people accept it, we got great ideas for part two already. We've got a great sequel for all the characters and back stories that are so remarkable."

Q: Sounds like you're creating your own Marvel universe in a sense.

A: "Essentially, yes."

(Reporting by Zorianna Kit, editing by Jill Serjeant)

Source: http://news.yahoo.com/minute-rapper-rza-putting-iron-fists-movie-145345208.html

chrissy teigen chia seeds embers shannon brown mike rowe shld 2012 sec football schedule

Mood of the Nation: Business owner spending less

MIAMI (AP) ? On the eve of the 2012 elections, The Associated Press interviewed dozens of Americans to try to gauge the economic mood of the nation. People were asked about jobs, housing, gas prices, retirement and other issues. Among them was Hilda Mitrani, 51, of North Miami Beach, Fla. The Great Recession and slow economic recovery have devastated her public relations and marketing business. But Mitrani says positive signs are emerging.

___

Mitrani's long-time clients are spending cautiously, if at all ? and she has had to adjust her own lifestyle as a result.

She delays making home repairs. She keeps an eye on the thermostat. And only occasionally, she's able to treat herself to a new pair of shoes.

"It's been a hard recovery," says the single mother of two children.

Mitrani is among many feeling squeezed by a painfully sluggish economic rebound. Unemployment remains high at 7.8 percent. Average pay trails inflation. And the economy is growing too slowly to accelerate hiring.

Mitrani's clients in the nonprofit and health care sectors are reluctant to spend on public relations when they may need that money for supplies or other basics, she says. So Mitrani, who used to employ two part-time workers, now runs the business alone.

But even with lower overhead, she still feels squeezed.

"You're not sure if you're going to get paid this month or next month, or if you're going to have a new client to replace the project that you just finished," she says.

Routine utility bills feel like a burden. And thinking about college tuition payments ? her daughter is a junior at Washington University in St. Louis ? is "nerve-wracking."

More than anything else, though, she laments the endless string of payments for insurance. "Between the car, the house, the health ? so much of the income goes to insurance that it's hard to get ahead," she says.

She rations healthcare for herself to cut down on co-pays. And when her daughter needed medical attention earlier this year, she found herself saying dueling prayers in the hospital.

"Please don't let this cost an arm and a leg. And please let her be OK," Mitrani recalls saying.

Mitrani is resigned to the fact that her retirement won't be as comfortable as her parents'. Compared with her parents' generation, Mitrani believes Americans today are a bit more materialistic and might need to ratchet back expectations a bit. There's evidence this is happening: Consumers have been saving and reducing debts more, and spending less, than before the financial crisis.

Still, Mitrani sees some reason for optimism. The stock market is coming back: The Standard & Poor's 500 stock index is up more than 12 percent this year. And slowly, clients are beginning to inquire about using her services in 2013.

"They're asking for proposals and planning expansions," she says. "They're starting to talk about the future."

__

To watch video of Mitrani and for more on this topic, go to: http://bigstory.ap.org/topic/mood-of-the-nation

__

AP video journalist Robert Ray contributed to this report.

Source: http://news.yahoo.com/mood-nation-business-owner-spending-less-040245162.html

Iron Man 3 marco scutaro Kendrick Lamar Russell Means Taylor Swift Red Register To Vote Walking Dead Season 3 Episode 2

Recent findings may help to fight melanoma's resistance to chemotherapy

Recent findings may help to fight melanoma's resistance to chemotherapy [ Back to EurekAlert! ] Public release date: 30-Oct-2012
[ | E-mail | Share Share ]

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

IRIC discovery could lead to better treatment of skin cancers

This press release is available in French.

Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC). "Our findings reveal part of the mechanisms responsible for the resistance of melanoma to anti-cancer treatments, and suggest that a particular protein in our bodies called RSK may be targeted in combination therapies to overcome drug resistance," Roux explained.

Although melanoma accounts for only 4% of all skin cancers, it is responsible for 80% of skin cancer-related deaths worldwide as it is highly invasive and resistant to conventional chemotherapies. Melanoma originates from pigment-producing cells, called melanocytes, located in the skin. The incidence of malignant melanoma is growing rapidly worldwide and there is still no effective therapy to treat it. Approximately 160,000 new cases of the disease are diagnosed each year.

Roux and his team focused their research on a signaling pathway called Ras/MAPK, which is often deregulated in melanoma, but also in lung, colon and pancreatic cancers. A signaling pathway is a chemical chain reaction that causes the cells in our bodies to act in a certain way. In this study, Roux and his team found that a protein in the Ras/MAPK pathway, RSK, contributes to chemoresistance by altering the response of cancer cells to chemotherapeutic agents.

This is the second Oncogene publication for Philippe Roux this year. In a paper published in July, Roux and his colleagues, IRIC Principal Investigators Katherine Borden and Sylvain Meloche, demonstrated that the same protein involved in chemoresistance contributes to melanoma growth, making the protein RSK a promising therapeutic target for treating the disease.

###

The study was made possible thanks to grants from the Canadian Cancer Society Research Institute and the Cancer Research Society.

Paper cited

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance H Ray-David, Y Romeo, G Lavoie, P Dlris, J Tcherkezian, J A Galan and P P Roux Oncogene advance online publication, October 29, 2012; doi:10.1038/onc.2012.472

About Philippe Roux

Philippe Roux is Principal Investigator of the Cell Signalling and Proteomics research unit at the Institute for Research in Immunology and Cancer (IRIC) and Associate Professor in the Department of Pathology and Cell Biology at the Faculty of Medicine of the Universit de Montral. He holds the Canada Research Chair in Signal Transduction and Proteomics and holds a Career Development Award from the Human Frontier Science Program (HFSP). For more information about Philippe Roux, please visit www.rouxlab.org.

About IRIC | Institute for Research in Immunology and Cancer

An ultra-modern research hub and training centre located in the heart of Universit de Montral, the Institute for Research in Immunology and Cancer (IRIC) was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague. IRIC operates according to a model that is unique in Canada. Its innovative approach to research has already led to discoveries that will, over the coming years, have a significant impact on the fight against cancer. For more information about IRIC, please visit www.iric.ca.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Recent findings may help to fight melanoma's resistance to chemotherapy [ Back to EurekAlert! ] Public release date: 30-Oct-2012
[ | E-mail | Share Share ]

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

IRIC discovery could lead to better treatment of skin cancers

This press release is available in French.

Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC). "Our findings reveal part of the mechanisms responsible for the resistance of melanoma to anti-cancer treatments, and suggest that a particular protein in our bodies called RSK may be targeted in combination therapies to overcome drug resistance," Roux explained.

Although melanoma accounts for only 4% of all skin cancers, it is responsible for 80% of skin cancer-related deaths worldwide as it is highly invasive and resistant to conventional chemotherapies. Melanoma originates from pigment-producing cells, called melanocytes, located in the skin. The incidence of malignant melanoma is growing rapidly worldwide and there is still no effective therapy to treat it. Approximately 160,000 new cases of the disease are diagnosed each year.

Roux and his team focused their research on a signaling pathway called Ras/MAPK, which is often deregulated in melanoma, but also in lung, colon and pancreatic cancers. A signaling pathway is a chemical chain reaction that causes the cells in our bodies to act in a certain way. In this study, Roux and his team found that a protein in the Ras/MAPK pathway, RSK, contributes to chemoresistance by altering the response of cancer cells to chemotherapeutic agents.

This is the second Oncogene publication for Philippe Roux this year. In a paper published in July, Roux and his colleagues, IRIC Principal Investigators Katherine Borden and Sylvain Meloche, demonstrated that the same protein involved in chemoresistance contributes to melanoma growth, making the protein RSK a promising therapeutic target for treating the disease.

###

The study was made possible thanks to grants from the Canadian Cancer Society Research Institute and the Cancer Research Society.

Paper cited

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance H Ray-David, Y Romeo, G Lavoie, P Dlris, J Tcherkezian, J A Galan and P P Roux Oncogene advance online publication, October 29, 2012; doi:10.1038/onc.2012.472

About Philippe Roux

Philippe Roux is Principal Investigator of the Cell Signalling and Proteomics research unit at the Institute for Research in Immunology and Cancer (IRIC) and Associate Professor in the Department of Pathology and Cell Biology at the Faculty of Medicine of the Universit de Montral. He holds the Canada Research Chair in Signal Transduction and Proteomics and holds a Career Development Award from the Human Frontier Science Program (HFSP). For more information about Philippe Roux, please visit www.rouxlab.org.

About IRIC | Institute for Research in Immunology and Cancer

An ultra-modern research hub and training centre located in the heart of Universit de Montral, the Institute for Research in Immunology and Cancer (IRIC) was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague. IRIC operates according to a model that is unique in Canada. Its innovative approach to research has already led to discoveries that will, over the coming years, have a significant impact on the fight against cancer. For more information about IRIC, please visit www.iric.ca.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-10/uom-rfm103012.php

the descendants the descendants homeland homeland packers giants game golden globe winners 2012 ricky gervais golden globes

Monday, October 29, 2012

Labrinth, Taylor Swift top UK music charts

{ttle}

{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"7664811","sec":""}}},{"id": "hcm-carousel-952855544", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-952855544", "track_item_selected":1,"tracking":{ "spaceid" : "7664811", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp = new XMLHttpRequest(); else xmlhttp = new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "7664811" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });

Tuesday, October 23, 2012

Officials see delay before northern Mali offensive

LONDON (AP) ? Western officials say a planned military push to reclaim northern Mali from al-Qaida-linked rebels is unlikely to begin before next year ? despite concerns about an escalating terrorist threat posed by the militants there.

Britain's special representative to the Sahel, Stephen O'Brien, said Tuesday that nations seeking to support Mali's government will spend several months working out what assistance the West African country requires. A U.N. Security Council resolution will be needed to authorize a military offensive, which would be African-led.

O'Brien says "That will all, around the turn of the year, start developing a very clear twin track approach ? on both the political and the possible military side."

Ex-Italian Premier Romano Prodi, U.N. special envoy to the Sahel, also indicated Tuesday that planning may take some time.

Source: http://news.yahoo.com/officials-see-delay-northern-mali-offensive-144008211.html

wade phillips wade phillips time person of the year sag nominations sag nominations time magazine person of the year time magazine person of the year

Romney, Obama Take Break from Campaign Trail for Jokes

President Barack Obama and Republican challenger Mitt Romney took a brief break from the campaign trail to appear at the 67th Annual Alfred E. Smith Memorial Foundation Dinner in New York on Thursday. The event is organized by the Catholic Archdiocese every year as a fundraising dinner to benefit children's charities.

The dinner gave the two candidates the opportunity to lightly roast each other for charity, as well as get in some self-deprecating humor about themselves to please the crowd. Romney and Obama will next meet on Monday for the third and final presidential debate before the elections.

Here are some of the highlights to emerge from Romney's and Obama's attendance at the Al Smith dinner on Thursday.

* Cardinal Timothy Dolan, who is the archbishop of New York, sat between the two men at the event, according to reports by the New York Times and other media outlets. Dolan spoke at both the Republican and the Democratic National Conventions this year.

* The Al Smith dinner is named for the first Catholic presidential candidate, Alfred E. Smith, who was also at one time a Democratic governor of New York. Attendance at the event is largely considered to be obligatory for any presidential candidate, according to a Reuters report.

* Reuters also made mention of the two men's mutual comedic target during the event, Vice President Joe Biden. Romney joked with the crowd that Biden's public statements often appeared to work his campaign's favor, telling attendees that the vice president's television appearances should be followed by the tagline "I'm Mitt Romney and I approve this message."

* While the tone of the evening was mostly light, both men managed to get in some subtle political digs regarding the economy, taxes, and other topics.

* They also each managed to aim their jabs at themselves, with Romney alluding to his assertion that he would cut funding to PBS by joking that "Big Bird didn't see it coming." Obama, for his part, targeted his widely panned performance in the first presidential debate, saying that he did better in the two men's second meeting this past Tuesday because he "felt really well-rested after the nice, long nap I had in the first debate," as quoted by ABC/OTUS News.

Source: http://news.yahoo.com/romney-obama-break-campaign-trail-jokes-162000475.html

obama trayvon martin pietrus cheney tori spelling marion barber marion barber syracuse

Monday, October 22, 2012

Avail Best Discount Coupons for Sports Accessories

Oct 21, 2012

For a sportsperson, having high-end sports gear equipment and accessories are very important and buying such sports merchandises is really difficult because of high cost tags, where most of them will suppress their interest of buying them. Shopping through traditional way is really very tough and selecting the desired product by visiting various stores for searching different brands is really a complicated task.
Online shopping has bought new innovations into scope, where shopping for sports accessories has became really very easy. While making an online purchase of sports gear, quality of an item is very important as best quality gives you best durability. As in traditional way, where we need to visit different stores in finding the latest brands with offers, online shopping provides an opportunity to purchase the latest brands for sports accessories by offering many discounts as they provide discount coupons and promo coupon codes on every purchase.
As online shopping is available for 24 hrs a day, you can shop for latest sports gear brands along with discount coupon codes by just a click of a mouse, while sitting in front of the computer screen. The customer market for sports gear is incredibly increasing due to many of its price saving features; most of the people are showing interest in purchasing the sports accessories online.
Online discount shopping for sports merchandise allows user to give proper attention on the purchase of sports accessories from large selection of jackets, running shoes, sandals, hiking boots, backpacks, shirts, shorts, pants, sunglasses, hats, baseball, softball, surf and skate equipments purchase. Also, it allows you to trawl the web as many times, but be vigilant to trawl right website that offers discount deals as there is a chance of being trapped by fake websites, but nowadays almost all websites are SSL encrypted in order to safeguard your account details.
One essential thing while dealing with sports accessories is its quality. You find many websites that provide best quality sports accessories with many discount coupon codes and promo coupons. It doesn't mean that we get cheap quality products at discount rate; it is just the way where online retailers will attract their customers by providing discount coupon codes online, on best quality products.
As a smart shopper, you must check for free shipping of sports accessories, besides discount coupons. Free shipping allows delivering your product in more secured and convenient way at your door step.
People looking for best discount deals and promo coupons can visit "www.couponsanddealz", a 24hr online website where you find best clearance on your shopping and get great discount deals offered by the latest and high quality sports merchandises like
? LACROSSE.COM
? HOMERUNMONKEY
? TWO SEASONS
? EASTERN MOUNTAIN SPORTS
? SPIRIT LINE
? WORLD WIDE GOLF SHOPS
Where, we can get branded sports accessories that offer enormous savings and great discounts on all your purchases.
Thus, as a sports lover, make your shopping memorable by purchasing great sports gear brands along with free shipping, which gives great value to your money.

About the Author

Couponsanddealz is an online discount shop where you can get all of your coveted products. The range of availability starts from Accessories to Automotive, from Books to Fitness items and from Electronics to Web Services. The site has got a huge list of 3,000 online discount stores and offering more than 200k current coupon codes on the internet. Now to avail the best discount offer come to our site and use our exclusive Discount Coupon Codes.
www.couponsanddealz.com

Rating:

(Average: Not rated)

Views: 17

Source: http://www.artipot.com/articles/1411807/avail-best-discount-coupons-for-sports-accessories.htm

one republic michael dyer suspended new years ball drop new years rockin eve new york times square jaws first night

How to Manage Two Personal Brands | Business 2 Community

Personal branding requires you to craft a professional image by communicating your unique interests, skills, and expertise. Your personal brand should reflect not only your professional interests, but it should also provide specific insight into your industry to show others what you know. But what happens if you need to promote two very different personal brands?

There are plenty of individuals who have varied interests and professional identities. Perhaps a political blogger is also pursuing side projects in photography. Or a high school teacher is looking to start a network for other adults interested in environmentalism.

Whatever the case, having multiple professional images to maintain can create a rift in your identity. You don?t want to risk alienating part of your audience, but you also need to promote two different focuses. Luckily, you have a few options for this juggling act. The beauty of it is, you can choose whatever option works best for you:

Fine-tune your focus. Determine which aspects of your brand actually need to be promoted. If you run a small business but also work as a public speaker, you may find you have a greater need to promote your public speaking career rather than a business that people are able to find through other outlets, like advertisements or word-of-mouth. That doesn?t mean you need to wipe your business from your professional online presence?for example, you can include that you?re a small business owner in your LinkedIn bio, but focus your blogging efforts on public speaking insights.

Segment your brands. Some may find it best to completely separate their two focuses. This could involve creating separate Twitter accounts: for instance, one for your graphic design work and insight, another for your 9-to-5 at a marketing company. This doesn?t mean you have to have a secret, split personality?feel free to include links to your other Twitter account, blog, website, or portfolio so that your audience can easily browse both of your professional interests.

Merge your brands. This option can be tricky, but many people find it?s easiest to simply communicate that they have a multi-faceted professional image. This is because many workers don?t have the time to manage multiple online profiles, nor do they want to risk dramatically segmenting their audience. Merge your brands by clarifying in your Twitter bio or on your LinkedIn page that you?re a teacher by day, environmentalist by night, and share information and insight relevant to both professional images. If you?re clear about both interests, your audience should have no problem finding the information most relevant to them.

Personal branding involves a tricky balance no matter what your career aspirations. Promoting multiple professional focuses often depends on what you find most manageable. Weigh the options above to determine what?s best for you?good luck!

Author:

Heather R. Huhman is a career expert, experienced hiring manager, and founder & president of Come Recommended, a content marketing and digital PR consultancy for organizations with products that target job seekers and/or employers. She is also the author of Lies, Damned Lies & Internships (2011), #ENTRYLEVELtweet: Taking Your Career from Classroom to Cubicle (2010), and writes career and recruiting advice for numerous outlets.

Source: http://www.business2community.com/strategy/how-to-manage-two-personal-brands-0308463

dodd frank Lark Voorhies gary johnson gary johnson Jennifer Livingston Orlando Cruz MLB Playoff Schedule

In Iran, not even prisoners want to hang out with Ahmadinejad

{ttle}

{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"2146021373","sec":""}}},{"id": "hcm-carousel-419046656", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-419046656", "track_item_selected":1,"tracking":{ "spaceid" : "2146021373", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp = new XMLHttpRequest(); else xmlhttp = new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "2146021373" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });

Sunday, October 21, 2012

Mystery in Gulf of Mexico: Why is oil leaking from Deepwater disaster site?

Oil identified as coming from the Macondo well, site of the 2010 Deepwater Horizon disaster, is leaking into the Gulf of Mexico at the rate of 100 gallons per day. The Coast Guard is investigating.

By Mark Guarino,?Staff writer / October 19, 2012

In this 2010 file photo, fire boat response crews battle the blazing remnants of the offshore oil rig Deepwater Horizon, off Louisiana.

U.S. Coast Guard/Reuters/Files

Enlarge

Oil is leaking into the Gulf of Mexico at the rate of about 100 gallons per day near the Macondo wellhead, the site of the oil spill over two years ago that became the worst environmental disaster in US history.

Skip to next paragraph

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

The US Coast Guard reports that the oil has been leaking since at least Sept. 16, when satellite images first revealed a sheen of surface oil located about 50 miles off the Louisiana coast and in the vicinity of where the Deepwater Horizon oil rig exploded on April 20, 2010, killing 11 people.

Five million barrels of oil, or 205 million gallons, were released into the Gulf in the three months following the explosion.

The sheen has varied in size since its detection. Samples taken to Coast Guard laboratories in Morgan City, La., and New London, Conn., concluded the oil originated from the Macondo well.

On Sunday, the Coast Guard dispatched remotely operated vehicles to collect oil samples from the underwater site. The agency reported on Wednesday it suspected the oil was leaking from a discarded containment dome, one of several technologies used to contain the original oil spill. The dome is located about 1,600 feet from the Macondo site.

In a statement, Capt. Duke Walker, on-scene coordinator for the Coast Guard, said the agency ?is further evaluating what is believed to be seepage from the containment dome to determine how best to respond.? The Coast Guard is not yet specifying how the oil could be seeping from the dome or what may be causing it to do so now.

BP, the British oil giant responsible for the 2010 drilling operation, reports that the Macondo wellhead remains sealed since it was permanently capped with cement in mid-September 2010. The Coast Guard?s underwater inspection Sunday double-checked the wellhead as well as residual wreckage from the explosion.

The containment dome, standing four stories high and weighing 98 tons, was lowered 5,000 feet below the water?s surface to the ocean?s floor on May 6, 2010, just weeks after the explosion. The device was originally meant as a temporary measure to contain the gushing oil from one of two main leaks while recovery crews worked to plug the well. The dome?s design allowed oil and gas to flow through a pipe to a surface vessel.

Five days later, however, the dome failed after methanol, combined with freezing undersea water, crystallized in the dome, making it buoyant. Filled with flammable material, the device floated to the surface, but engineers later manipulated it so it could rest safely on the ocean?s floor.

Following the oil spill, the Obama administration issued stricter regulations for companies drilling in the deep waters of the Gulf, which is the largest source of domestic oil in the US. Despite a temporary moratorium on drilling in the region in the immediate aftermath of the disaster, permits for drilling new wells in water deeper than 500 feet are up to pre-disaster levels.

According to the US Bureau of Safety and Environmental Enforcement, the agency tasked with regulating offshore drilling, the US has to date issued 89 permits this year, more than all the permits issued (76) in 2009, one year before the disaster. The agency?s website reports that 32 permits were issued in 2010 and 38 in 2011.

The issue of drilling on federal lands became a contentious issue in Tuesday?s debate between Republican presidential candidate Mitt Romney and President Obama. In the debate, Mr. Romney accused the president of slashing permits for drilling in half during his administration. Mr. Obama denied the accusation.

The increased pace of permitting has pleased some oil and gas industry analysts, who say the administration is on the right path.

?We?re just now seeing the permitting return to pre-Macondo levels,? Andy Lipow, president of the Houston-based consulting firm Lipow Oil Associates LLC, told Bloomberg News Wednesday. ?With oil prices hovering around $90 to $100 a barrel, it makes sense to look for oil in that area.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/VnpB78LvfRI/Mystery-in-Gulf-of-Mexico-Why-is-oil-leaking-from-Deepwater-disaster-site

nicklas backstrom discovery shuttle allure jane goodall saturday night fever glamping forgetting sarah marshall

15 Unbelievable Halloween Makeup Tutorials on YouTube

{ttle}

{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"7665149","sec":""}}},{"id": "hcm-carousel-291732443", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-291732443", "track_item_selected":1,"tracking":{ "spaceid" : "7665149", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp = new XMLHttpRequest(); else xmlhttp = new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "7665149" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });

Lawyers, CEOs boosted Obama's Sept. donations

'},"otherParams":{"t_e":1,".intl":"US"},"events":{"fetch":{lv:2,"sp":"2146372232","ps":"LREC,MON","npv":true,"bg":"#FFFFFF","em":escape('{"site-attribute":"\'Candidates\'=\'Barack Obama;Mitt Romney\' \'Political Keywords\'=\'Barack Obama;Mitt Romney\' _id=\'5731db49-2a1e-3628-8dec-5439167aa585\' sensitivity=\'0\' rs=\'lmsid:a077000000IpoJiAAJ\' ctype=\'fn_news;News\' ctopid=\'1996000;12830500;2067000;9174489;2063500\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}'),"em_orig":escape('{"site-attribute":"\'Candidates\'=\'Barack Obama;Mitt Romney\' \'Political Keywords\'=\'Barack Obama;Mitt Romney\' _id=\'5731db49-2a1e-3628-8dec-5439167aa585\' sensitivity=\'0\' rs=\'lmsid:a077000000IpoJiAAJ\' ctype=\'fn_news;News\' ctopid=\'1996000;12830500;2067000;9174489;2063500\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}')}}};var _createNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);var nodeHTML;if(center && !node){nodeHTML=_conf.nodes[nId];center.insert(nodeHTML);};};};var _prepareNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-ad-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);if(center && node){center.set("innerHTML","");center.insert(node);node.setStyle("display","block");};};};var _darla;var _config=function(){if(YAHOO.ads.darla){_darla = YAHOO.ads.darla;_createNodes();};};var _fetch=function(spaceid,adssa,ps){ if (typeof(ps)!='undefined') _conf.events.fetch.ps = ps;if(typeof spaceid != "undefined") _conf.events.fetch.sp=spaceid;adssa = (typeof adssa != "undefined" && adssa != null) ? escape(adssa.replace(/\"/g, "'")) : "";_conf.events.fetch.em=_conf.events.fetch.em_orig.replace("ADSSA", adssa);if(_darla){_prepareNodes();_darla.setConfig(_conf);_darla.event("fetch");};};Y.on("domready", function(){_config();});;var that={"fetch":_fetch,"getNodes":_conf.nodes,"getConf":_conf};return that;}();/* Backwards compatibility - Assigning the latest instance to the main fetch function */YUI.PhotoAdsDarla.fetch=YUI.PhotoAdsDarla.photoslightboxdarla.fetch; }); Y.later(10, this, function() {YAHOO.namespace('Media.Social').Lightbox = {}; }); Y.later(10, this, function() {Y.Media.Article.init(); }); Y.later(10, this, function() {new Y.Media.AuthorBadge(); }); Y.later(10, this, function() {new Y.Media.Branding(); }); Y.later(10, this, function() {Y.on("load", function () { YUI.namespace("Media.SocialButtons"); var instances = YUI.Media.SocialButtons.instances || [], globalConf = YAHOO.Media.SocialButtons.conf || {}, vplContainers = []; Y.all(".ymsb").each(function (node) { var id = node.get("id"), conf = YAHOO.Media.SocialButtons.configs[id], instance; if (conf) { instance = new Y.SocialButtons({ srcNode: node, config: Y.merge(globalConf, conf.config || {}), contentMetadata: conf.content || {}, tracking: conf.tracking || {} }); vplContainers.push( { selector: "#" + id, callback: function(node) { instance.render(); instance = conf = id = null; } }); if (conf.config && conf.config.dynamic) { instances.push(instance); } } }); Y.Global.Media.ViewportLoader.addContainers(vplContainers); YUI.Media.SocialButtons.instances = instances; }); }); Y.later(10, this, function() {if (!Y.Media) { return; } Y.Media.boba_lightbox_module_targets = Y.Media.boba_lightbox_module_targets || {}; Y.Media.boba_lightbox_module_configs = Y.Media.boba_lightbox_module_configs || {}; Y.Media.boba_lightbox_module_dataset = Y.Media.boba_lightbox_module_dataset || {}; Y.Media.boba_lightbox_module_whitelist = Y.Media.boba_lightbox_module_whitelist || {}; Y.Media.boba_lightbox_module_dataset['993912ada1924f134c0b41bd51c4bf36'] = []; Y.Media.boba_lightbox_module_configs['993912ada1924f134c0b41bd51c4bf36'] = {"spaceid":"2146372232","ult_pt":"story-lightbox","darla_id":"","images_total":0,"xhr_url":"\/_xhr\/related-article\/lightbox\/?id=5731db49-2a1e-3628-8dec-5439167aa585","xhr_count":20,"autoplay_if_first_item_is_video":true}; }); Y.later(10, this, function() {new Y.Media.RelatedArticle({count:"2",start:"1", mod_total:"10", total:"0", content_id:"5731db49-2a1e-3628-8dec-5439167aa585", spaceid:"2146372232", related_count:"-1" }); }); Y.later(10, this, function() {(function(d){ d.getElementsByTagName('head')[0].appendChild(d.createElement('script')).src='http://d.yimg.com/oq/js/csc_news-en-US-core.js'; })(document); }); Y.later(10, this, function() { if(!("Media" in YAHOO)){YAHOO.Media = {};} if(!("ugcrate" in YAHOO.Media)){YAHOO.Media.ugcrate = {};} if(!("Media" in Y)){Y.namespace("Media");} YAHOO.Media.ugcrate.ratings_3af23228d41bc83e50848fa9cd044e30 = new Y.Media.UgcRate({"context_id":"4b73f06a-bc4d-4ef4-826d-338a8c9551c6","sCrumb":"","containerId":"yom-sentimentrate-3af23228d41bc83e50848fa9cd044e30","rateDimensions":"d1","appLang":"en-US","sUltSId":"2146372232","sUltProperty":"news-en-US","sUltCampaign":"","sUltPlatform":"ugcwidgets","sUltIntl":"US","sUltLang":"en-US","selfPageUrl":"http:\/\/news.yahoo.com\/lawyers-ceos-boosted-obamas-sept-donations-013650041--election.html?_esi=0","artContentId":"5731db49-2a1e-3628-8dec-5439167aa585","sUltQstnTxt":"Are Social Security and Medicare crucial to your retirement security?","artContentTitle":"Lawyers, CEOs boosted Obama\\'s Sept. donations","artContentDesc":" Attorneys, business owners and retirees were among those who helped President Barack Obama maintain slim fundraising supremacy over Republican challenger Mitt Romney last month, with the president raising $181 million as he entered the last full month in the fight to keep his job.","sUltBucketId":"test1","sUltSection":"sentirating","sUltBeaconUrl":"","sUltRecordPageviews":"1","sUltBeaconEnable":"1","serviceUrl":"\/_xhr","publisherContextId":"","propertyId":"2fcd79b5-b3a3-333e-b98e-722536a6698f","configurationId":"435db9ee-c55e-3766-b20d-c8ad3ff889d1","graphId":"","labelLeft":"Not at all","labelRight":"Crucial","labelMiddle":"","itemimg":"http:\/\/l.yimg.com\/a\/i\/ww\/met\/yahoo_logo_us_061509.png","selfURI":"","aggregateRatingCount":"251899","aggregateReviewCount":"0","leftBlocksNum":"57833","rightBlocksNum":"193994","leftBlocksPerCent":"23","rightBlocksPerCent":"77","ugcrate_apihost":"api01-us.ugcl.yahoo.com:4080","publisher_id":"news-en-US","yca_cert":"yahoo.ugccloud.app.trusted_proxies","timeout_write":"5000","through_proxy":"false","optionStats":"{\"s1\":22204,\"s2\":7155,\"s3\":6878,\"s4\":10022,\"s5\":11574,\"s6\":193994,\"s7\":0,\"s8\":0,\"s9\":0,\"s10\":0}","l10N":"{\"FIRST_TO_READ\":\"You are first to read this. Share your feelings and start a conversation.\",\"SHARE_YOUR_FEELINGS\":\"You too can share your feelings and start a conversation!\",\"HOW_YOUR_FRIENDS_THINK\":\"Share your opinion with your friends.\",\"PRE_SHARE_MSG\":\"Your Facebook friends on Yahoo! can see how you responded to this question. To share your response on Facebook, click on the Facebook share option.\",\"START_THE_CONVERSATION\":\"Share\",\"THANKS_FOR_SHARING\":\"Thanks!\",\"POLL_HEADER\":\"SOCIAL SENTIMENT\",\"SERVER_ERROR\":\"Oops there seems to be some error, please try again later\",\"LOADING\":\"Loading...\",\"SHARE_AFTER_COMMENT\":\"Your response has been shared on Facebook.\",\"UNDO\":\"Undo\",\"UNIT_PEOPLE\":\"People\",\"NUM_PEOPLE_DISAGREE\":\"disagree with your opinion.\",\"READ_MORE_TEXT\":\"Read what they have to say.\",\"SLIDER_THUMB_WORDING_BEFORE_VOTING\":\"WHAT DO YOU THINK?\",\"SLIDER_THUMB_WORDING_VERB_BEFORE_VOTING\":\"DRAG\",\"SLIDER_THUMB_WORDING_THANKS_VOTING\":\"Thanks for voting\",\"NUM_PEOPLE_ANSWERED\":\" 251,899 people have answered this question\",\"ONE_PERSON_ANSWERED\":\" 1 person has answered this question\",\"TWO_PEOPLE_ANSWERED\":\" 2 people have answered this question\",\"NUM_PEOPLE_RATED__s1\":22204,\"NUM_PEOPLE_RATED__s2\":7155,\"NUM_PEOPLE_RATED__s3\":6878,\"NUM_PEOPLE_RATED__s4\":10022,\"NUM_PEOPLE_RATED__s5\":11574,\"NUM_PEOPLE_RATED__s6\":193994,\"NUM_PEOPLE_RATED__s7\":0,\"NUM_PEOPLE_RATED__s8\":0,\"NUM_PEOPLE_RATED__s9\":0,\"NUM_PEOPLE_RATED__s10\":0}","fbconfig":"{\"message\":\"undefined\",\"name\":\"undefined\",\"link\":\"\",\"source\":\"\",\"picture\":\"http:\\\/\\\/l.yimg.com\\\/os\\\/152\\\/2012\\\/07\\\/12\\\/slidermedi-jpg_181904.jpg\",\"description\":\"There are quite a few things to consider when thinking about retirement.\",\"captionLeft\":\"undefined\",\"captionRight\":\"undefined\",\"app_id\":\"196660913708276\",\"redirect_uri\":\"\\\/_xhr\\\/ugcratefbredirect\\\/\"}","template_id":"LONG_SLIDER_SOUTH","obj_id":"ratings_3af23228d41bc83e50848fa9cd044e30","opt_count":"6","opt_color1":"","opt_color2":"","template_html":"

Source: http://news.yahoo.com/lawyers-ceos-boosted-obamas-sept-donations-013650041--election.html

tax day april 17 boston marathon tu pac hologram shuttle pippa middleton space shuttle discovery

Friday, October 19, 2012

Branding company to attract business investors to Chile

International branding company Common will come to Santiago next month for its first appearance in Latin America, bringing with it a cast of prominent speakers including former U.S. Vice President Al Gore.

Common Pitch Chile, a three-day event of speakers, workshops and live music, is devoted to creating conversations and sharing ideas about innovative enterprise and social change. The festival is in partnership with Start-Up Chile, a government program seeking to attract high-potential entrepreneurs and startups to launch in Chile.

Beginning on Nov. 29, the event will feature a full cast of ?rock star? speakers including former US Vice President and Nobel Peace Prize Laureate, Al Gore; founder of historical rock band Soda Stereos and the R21 foundation, Charly Alberti; and Google X Director of Experience, Tom Chi. Other speakers include Suroosh Alvi, David Cohen and Sharon Vosmek, among many other mentors and entrepreneurs.

More Here (Santiago Times)

Source: http://www.gringos.com/forum/f141/branding-company-attract-business-investors-chile-13850/

Aly Raisman Marvin Hamlisch Megan Rossee NASA

Non-coding antisense RNA can be used to stimulate protein production

Wednesday, October 17, 2012

While studying Parkinson's disease, an international research group made a discovery which can improve industrial protein synthesis for therapeutic use. They managed to understand a novel function of non-protein coding RNA: the protein synthesis activity of coding genes can be enhanced by the activity of the non-coding one called "antisense."

To synthesize proteins, the DNA needs RNA molecules serving as short "transcriptions" of the genetic information. The set of all these RNA molecules is called "transcriptome." In the human transcriptome, along with around 25 thousand sequences of coding RNA (i.e. the sequences involved in the synthesis process), an even larger number of non-coding RNA sequences can be found. Some of these RNAs are called "antisense" because they are complementary to sequences of coding RNA called "sense" (the pairing of a sense and an antisense RNA can be seen as a zip).

The RIKEN Omics Science Center has previously discovered that many of the protein coding genes have corresponding antisense RNAs. A study published in Nature, coordinated by a group of SISSA researchers in Trieste, Italy, has now found that a particular type of antisense RNAs stimulate the translation of the protein coding mRNAs that they overlap to. This is in sharp contrast with the current belief that antisense RNAs are universally associated to negative regulation of protein translation.

Most of the mammalian genome is transcribed producing non-coding RNA. The RIKEN FANTOM projects have earlier demonstrated that the largest output of the genome is constituted by non-coding RNAs. More than 70% of the mRNAs are associated in cells with non-coding antisense RNAs, which are usually thought to negatively repress transcription or translation.

In an exceptional collaborative study based on RIKEN FANTOM sense-antisense cDNA clones, the consortium (including SISSA and the RIKEN Omics Science Center) has found a class of non-coding antisense RNAs that do the contrary of what is currently known: enhance translation of mRNAs with which they are pairing. The researchers identified this function studying the antisense of the mRNA of Uchl1, a mouse gene involved in brain function and neurodegenerative diseases. The team, using bioinformatics and data-mining at RIKEN, has also discovered that the antisense of Uchl1 RNA is not a single case but instead is the representative of a larger class of mammalian antisense RNAs, which function is to increase translation. This is the first report of an antisense RNA that increases protein production, which works both in mouse and human cells and is predicted to have similar function in other organisms.

The mechanism to stimulate translation is based on increased association of mRNAs with ribosomes, which is mediated by a SINEB2 element, a repetitive sequence in the antisense of Uchl1 RNA, which is placed in an inverted orientation in the non-coding RNA. The specificity is given by a short antisense RNA sequence that hybridizes with the initial part of the protein encoding mRNA.

Why is it an important discovery?

Very little used to be known about "long, non-coding" RNAs and this new research sheds light on some of these molecules. "We focused on one gene, Uchl1, whose mutations are linked to some hereditary types of Parkinson's disease," stated Stefano Gustincich, Professor at SISSA. "We have seen that the non-coding antisense RNA matched to this gene is made up of two fragments, the real antisense fragment matching with the sense RNA that codifies the protein and the SineB2 sequence. The antisense fragment has the function of a 'lock' into which the key of the coding RNA specific for that gene is inserted, while the other one has a stimulating function on protein synthesis."

If you change the antisense fragment with the analogous of another gene, the SineB2 sequence maintains its stimulating function on the new gene. "This is important," explained Gustincich "because it means that the action of sineB2 could be used to stimulate protein production for therapeutic use ? any protein ? in industrial synthesis processes."

"We are delighted to see that there is one more function for long non-coding RNAs," says Piero Carninci, Team Leader at RIKEN OSC. "Since the initial discovery that the majority of the genome produces so many non-coding RNAs, there has been a general skepticism related to the possible function of these RNAs. This is a milestone study identifying a novel class of non-coding RNAs which have a key regulatory function, enhancing protein translation. Additionally, this function is mediated by repetitive elements, so far generally considered the 'junk' fraction of the genome, suggesting that the concept that most of the genome is 'junk' should be revisited. After all, there may be function embedded in any part of the genome, which we do not yet understand."

RIKEN and the RIKEN venture company TransSINE Technologies are committed to exploit commercial applications of this specific structure of the antisense RNA.

These RNAs, called SINEUPs, can be engineered to stimulate translation of other proteins, by changing the overlapping antisense region to target any protein of industrial or therapeutic interest. Initial target proteins will include therapeutic proteins, like antibodies or other soluble factors, as well as other basic studies to understand gene function by overexpression of proteins. RIKEN believes that this work can be broadly used.

###

Claudia Carrieri, Marta Biagioli, Laura Cimatti, Anne Beugnet, Isidre Ferrer, Silvia Zucchelli, Stefano Biffo, Allistar Forrest, Piero Carninci, Elia Stupka, and Stefano Gustincich. "Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat." Nature, 2012, DOI: 10.1038/nature11508

RIKEN: http://www.riken.jp/engn/

Thanks to RIKEN for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 24 time(s).

Source: http://www.labspaces.net/124522/Non_coding_antisense_RNA_can_be_used_to_stimulate_protein_production

apple earnings report john l smith apple earnings the glass castle jennifer hudson trial north korea threat brandon jacobs

Saturday, October 13, 2012

Leaked T-Mobile roadmap has dates for LG Optimus L9, Huawei Summit, and a color refresh for the Galaxy S2

T-Mo roadmap

The folks over at TmoNews got their hands on a leaked T-Mobile US roadmap for fall, and as expected there's several Android devices in the spotlight.

First up on October 29 is a "color refresh" for the Samsung Galaxy S2. This one has our interest, because nobody is quite sure what colors will be offered. as the original already comes in black or white. 

Following closely on October 31 is the release of the Huawei Summit, a previously unknown Android phone. The specs are nowhere to be seen, but it's a pretty safe bet to say this will be an entry level handset. There's a leaked render after the break of the Summit.

Also on October 31 is the scheduled release of the LG Optimus L9 (see our hands-on). While things like 4GB of onboard storage keep this one decidedly entry-level, our impression was that it's a surprisingly nice phone. At the right price, it could make quite a splash. 

Absent is the Galaxy Note 2, but we're not going to read too much into that. A device of that caliber will likely have a special launch of its own, and not be lumped with the rest of the fall lineup. 

Of course none of this is official until it's made official, but leaks and speculation are half the fun this time of year. Click through for the leaked Huawei Summit press shot

Source: TmoNews

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/B1OWVPaQUFQ/story01.htm

seattle times walker recall censor pipa and sopa sopa pipa wikipedia blackout kyla pratt